Topic: clinical trial
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mRNA Cancer Vaccine Shows 5-Year Protection, Moderna-Merck Data Reveals
A personalized mRNA vaccine combined with standard immunotherapy nearly halved the risk of recurrence or death in high-risk melanoma patients over five years compared to immunotherapy alone. The vaccine is custom-made for each patient using genetic markers from their tumor to train the immune sys...
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Butt Breathing Breakthrough: IgNobel Idea Nears Medical Reality
Enteral ventilation, a method of delivering oxygen through the colon, has shown promising safety results in its first human clinical trial and could serve as an emergency oxygen delivery method when traditional breathing is impossible. The technique uses an oxygen-rich liquid absorbed through the...
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Brain-Computer Interface Coming to Apple Vision Pro
Cognixion is testing a noninvasive brain-computer interface system paired with the Apple Vision Pro to help individuals with paralysis-induced speech disorders communicate by translating brain signals into commands. The company differentiates itself by avoiding surgical implants, using a speciali...
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Study: No Safe Exit for Some on GLP-1 Drugs
GLP-1 weight-loss medications lack a clear, evidence-based strategy for safe discontinuation, with patients often experiencing rapid reversal of health gains after stopping treatment. A JAMA Internal Medicine study found that stopping tirzepatide led to significant weight regain and loss of cardi...
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FDA Rejects Moderna's mRNA Flu Vaccine Application
The FDA rejected Moderna's application for its mRNA flu vaccine, citing concerns over the design of its pivotal clinical trial, which the company claims had received prior agency feedback. The agency specifically questioned the comparator vaccine used in Moderna's large Phase 3 study, even though...
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OTC Nasal Spray Cuts COVID Infections by 67% in Trial
An over-the-counter nasal spray containing azelastine significantly reduced COVID-19 infections by 67% in a clinical trial, offering an additional layer of protection. Participants using the spray took longer to test positive and cleared the virus faster, suggesting it delays viral establishment ...
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Smart Glasses and Eye Implant Restore Partial Vision
Researchers have restored partial vision in patients with age-related macular degeneration using a tiny retinal implant paired with smart glasses that capture and project images via near-infrared light. In a clinical trial, 26 out of 32 participants showed measurable visual improvement, enabling ...
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Trump official overruled FDA to reject Moderna flu shot
A top FDA political appointee, Vinay Prasad, unilaterally rejected Moderna's mRNA flu vaccine application, overriding the consensus of career scientists who were prepared to review it. Senior FDA scientists formally objected, arguing the rejection was misguided, as the agency had previously appro...
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